p6con Pax6 is a key regulatory gene for eye, brain, and pancreas development. It acts as a transcriptional activator and repressor. Loss-of-function of Pax6 results ...

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由 Y Yamaguchi 著作 1997 被引用 50 次 According to this model NTS is involved in the P6CON binding and the 5a insertion serves as a molecular switch to unmask the cryptic DNA binding activity of  由 S Lee 著作 2020 被引用 13 次 Since P6B and P6CON have similar DNA sequence to be recognized by PAX6 effects caused by PAX6 mutation could be quite similar to each other   Pax6 is a key regulatory gene for eye brain and pancreas development It acts as a transcriptional activator and repressor Loss of function of Pax6 results  由 BK Chauhan 著作 2004 被引用 85 次 Thus P6CON 5aCON and HDCON represent well the diversity of natural Pax6 DNA binding sites The PAX6 series of proteins bound to P6CON with apparently  由 N Azuma 著作 1999 被引用 150 次 In the present study the V54D mutation mildly increased P6CON binding activity and decreased transactivation via 5aCON a result that also fits with this model 

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4.9 out of 5 stars
525753 global ratings

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  • mega5575
    5.0 out of 5 starsVerified Purchase
    PAX6, Paired Domain Influences Sequence Recognition ...
    Reviewed in the Thailand on July 6, 2025
    由 N Azuma 著作 · 1999 · 被引用 150 次 — In the present study, the V54D mutation mildly increased P6CON-binding activity and decreased transactivation via 5aCON, a result that also fits with this model ...
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  • player_6375
    1.0 out of 5 starsVerified Purchase
    Impaired DNA-binding affinity of novel PAX6 mutations
    Reviewed in the Thailand on July 17, 2025
    Pax6 is a key regulatory gene for eye, brain, and pancreas development. It acts as a transcriptional activator and repressor. Loss-of-function of Pax6 results ...
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  • user7020
    1.0 out of 5 stars
    Gene regulation by PAX6: Structural-functional correlations of ...
    Reviewed in the Thailand on June 25, 2025
    由 BK Chauhan 著作 · 2004 · 被引用 85 次 — Thus, P6CON, 5aCON, and HDCON represent well the diversity of natural Pax6 DNA-binding sites. The PAX6 series of proteins bound to P6CON with apparently ...
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